# Johannes Kepler Symposium on Mathematics

As part of the Johannes Kepler symposium on mathematics
**Prof. Dr. Philipp
Kügler**, Universität Hohenheim,
will give a public talk (followed by a discussion) on **Thu, Sept. 20, 2012**
at **13:30 o'clock** at **S2 416**
on the topic of
"Parameter identification problems in physiology and systems biology"
. The organziers of the symposium,

Univ.-Prof. Dr. Gerhard Larcher

A.Univ.-Prof. Dr. Jürgen Maaß, and

die ÖMG (Österreichische Mathematische Gesellschaft),

hereby cordially invite you.

Series B - Mathematical Colloquium:

The intention is to present new mathematical results for an audience interested in general mathematics.

### Parameter identification problems in physiology and systems biology

Along with the advances in experimental techniques comes a transformation of life science into a highly quantitative discipline. While statistics and bioinformatics are widely used for data analysis, applied mathematics is more and more acknowledged as an equal contributor in the quest to understand the functional interactions of cellular components, organs and systems. Visions of this interdisciplinary approach include personalized medicine, computer designed drugs or large scale biofuel usage. With life being a dynamic process, modelling and simulation of biological systems often involves time-dependent differential equations and brings along a diversity of parameter identification problems. After a general introduction with links to papers collected in my habilitation thesis, I focus on two problem types related to biochemical reaction networks. One deals with moment-based inference of reaction rate parameters from repeated observations of molecule copy numbers, the other is about the manipulation of qualitative network behaviour for the return from diseased to healthy states.